Inhibition of Staphyloxanthin Virulence Factor Biosynthesis in Staphylococcus aureus: In Vitro, in Vivo, and Crystallographic Results

Author:

Song Yongcheng1,Liu Chia-I1,Lin Fu-Yang1,No Joo Hwan1,Hensler Mary1,Liu Yi-Liang1,Jeng Wen-Yih1,Low Jennifer1,Liu George Y.1,Nizet Victor1,Wang Andrew H.-J.1,Oldfield Eric1

Affiliation:

1. Department of Chemistry and Center for Biophysics and Computational Biology, University of Illinois at Urbana—Champaign, 600 S. Mathews Avenue, Urbana, Illinois 61801, Institute of Biological Chemistry, Academia Sinica, Nankang, Taipei 11529, Taiwan, National Core Facility of High-Throughput Protein Crystallography, Academia Sinica, Nankang, Taipei 11529, Taiwan, Institute of Biochemical Sciences, College of Life Science, National Taiwan University, Taipei 10098, Taiwan, Department of Pediatrics and...

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Reference27 articles.

1. Antimicrobial Resistance

2. Invasive Methicillin-Resistant Staphylococcus aureus Infections in the United States

3. Treating Infectious Diseases in a Microbial World: Report of Two Workshops on Novel Antibacterial Therapeutics;National Research Council:Washington, DC, 2006; pp21−22.

4. Identification of novel cytolytic peptides as key virulence determinants for community-associated MRSA

5. Antivirulence as a new antibacterial approach for chemotherapy

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