The development of thymol–isatin hybrids as broad-spectrum antibacterial agents with potent anti-MRSA activity-Reference-Cited by-同舟云学术

The development of thymol–isatin hybrids as broad-spectrum antibacterial agents with potent anti-MRSA activity

Published:2024 Issue:1 Volume:15 Page:234-253
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Singh Atamjit¹^ORCID,Kaur Kirandeep¹,Mohana Pallvi²,Singh Karanvir¹^ORCID,Sharma Aman¹,Prajapati Jignesh³,Goswami Dweipayan³,Khosla Neha⁴,Kaur Uttam⁵,Kaur Rajanbir²,Kaur Rajinder²,Rana Abhineet⁶,Kour Sandeep⁷,Ohri Puja⁷,Arora Saroj²,Chadha Renu⁸^ORCID,Singh Bedi Preet Mohinder¹⁹

Affiliation:

1. Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab 143005, India

2. Department of Botanical and Environmental Sciences, Guru Nanak Dev University, Amritsar, Punjab 143005, India

3. Department of Microbiology & Biotechnology, University School of Sciences, Gujrat University, Ahmedabad, Gujrat 380009, India

4. Department of Molecular Biology and Biochemistry, Guru Nanak Dev University, Amritsar, Punjab, 143005, India

5. University School of Business Management, Chandigarh University, Gharuan 140413, India

6. EMC Super Speciality Hospital, Amritsar, Punjab, 143005, India

7. Department of Zoology, Guru Nanak Dev University, Amritsar, Punjab, 143005, India

8. University Institute of Pharmaceutical Sciences, Punjab University, Chandigarh 160014, India

9. Drug and Pollution Testing Laboratory, Guru Nanak Dev University, Amritsar, Punjab 143005, India

Abstract

Triazole-tethered isatin-thymol hybrids are developed for targeting multidrug-resistant bacterial strains with efficacy against MRSA acting via CrtM inhibition. The most active hybrid showed bactericidal and antibiofilm efficacy against MRSA and was capable of rescuing larvae from in vivo infection.

Funder

University Grants Commission

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2024/MD/D3MD00580A

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