Design and Synthesis of Highly Potent and Isoform Selective JNK3 Inhibitors: SAR Studies on Aminopyrazole Derivatives-Reference-Cited by-同舟云学术

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Design and Synthesis of Highly Potent and Isoform Selective JNK3 Inhibitors: SAR Studies on Aminopyrazole Derivatives

Published:2014-11-21 Issue:23 Volume:57 Page:10013-10030
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Zheng Ke¹,Iqbal Sarah¹,Hernandez Pamela¹,Park HaJeung¹,LoGrasso Philip V.¹,Feng Yangbo¹

Affiliation:

1. Medicinal Chemistry, ‡Discovery Biology, §Crystallography/Modeling Facility, Translational Research Institute, and ∥Department of Molecular Therapeutics, Scripps Florida, The Scripps Research Institute, 130 Scripps Way, No. 2A1, Jupiter, Florida 33458, United States

Funder

U.S. Department of Defense

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm501256y

Reference57 articles.

1. Selective interaction of JNK protein kinase isoforms with transcription factors.

2. c-Jun N-terminal kinase (JNK) signaling: Recent advances and challenges

3. Blocking c-Jun N-terminal Kinase (JNK) Translocation to the Mitochondria Prevents 6-Hydroxydopamine-induced Toxicity in Vitro and in Vivo

4. Inhibition of JNK Mitochondrial Localization and Signaling Is Protective against Ischemia/Reperfusion Injury in Rats

5. Specific activities of individual c-Jun N-terminal kinases in the brain

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