Leveraging Synergistic Solubility in the Development of a Direct Isolation Process for Nemtabrutinib-Reference-Cited by-同舟云学术

Leveraging Synergistic Solubility in the Development of a Direct Isolation Process for Nemtabrutinib

Published:2023-03-10 Issue:4 Volume:27 Page:659-668
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Chen Yonggang¹,Iuzzolino Luca²^ORCID,Burgess Samantha A.³^ORCID,Chung Cheol K.¹^ORCID,Corry James¹,Crawford Morgan¹,Desmond Richard¹,Guetschow Erik³,Hartmanshenn Clara¹,Kuhl Nadine¹^ORCID,Liu Zhu³,Luo Hanlin³,McQuilken Alison C.³,Newman Justin A.³^ORCID,Ren Hong¹^ORCID,Thaisrivongs David A.¹^ORCID,Wang Zhixun¹^ORCID,Sirota Eric¹^ORCID

Affiliation:

1. Department of Process Research & Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States

2. Department of Modeling & Informatics, Merck & Co., Inc., Rahway, New Jersey 07065, United States

3. Department of Analytical Research & Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.2c00391

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5. Chen, Y.; Corry, J.; Desmond, R.; Di Maso, M. J.; Forstater, J.; Kuethe, J.; Kuhl, N.; Reed, L.; Levesque, F.; Narsimhan, K.; Otte, D.; Prier, C. K.; Shevlin, M.; Sirota, E.; Tan, L.; Thaisrivongs, D. A.; Turnbull, B. W. H.; Wang, Z.; Xiao, K.; Synthesis of BTK Inhibitor and Intermediates thereof, WO2022/251404 A1, 2022.

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