Bruton’s tyrosine kinase (BTK) function is important to the development and expansion of chronic lymphocytic leukemia (CLL)-Reference-Cited by-同舟云学术

Bruton’s tyrosine kinase (BTK) function is important to the development and expansion of chronic lymphocytic leukemia (CLL)

Published:2014-02-20 Issue:8 Volume:123 Page:1207-1213
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Woyach Jennifer A.¹,Bojnik Engin²,Ruppert Amy S.¹,Stefanovski Matthew R.¹,Goettl Virginia M.¹,Smucker Kelly A.¹,Smith Lisa L.¹,Dubovsky Jason A.¹,Towns William H.¹,MacMurray Jessica¹,Harrington Bonnie K.³,Davis Melanie E.¹,Gobessi Stefania²,Laurenti Luca⁴,Chang Betty Y.⁵,Buggy Joseph J.⁵,Efremov Dimitar G.²,Byrd John C.¹⁶,Johnson Amy J.¹⁶

Affiliation:

1. Division of Hematology, Department of Internal Medicine and Comprehensive Cancer Center, The Ohio State University, Columbus, OH;

2. Molecular Hematology, International Centre for Genetic Engineering and Biotechnology, Rome, Italy;

3. College of Veterinary Medicine, Department of Veterinary Biosciences, The Ohio State University, Columbus, OH;

4. Department of Hematology, Catholic University Hospital “A. Gemelli,” Rome, Italy;

5. Pharmacyclics, Inc., Sunnyvale, CA; and

6. Division of Medicinal Chemistry, College of Pharmacy, The Ohio State University, Columbus, OH

Abstract

Key Points Kinase-functional BTK is important in the development and expansion of CLL. Both targeted genetic inactivation of BTK and inhibition of BTK by ibrutinib inhibit the development of CLL in the TCL1 mouse model.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/8/1207/1378337/1207.pdf

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