Manufacturing Process Development for Uprifosbuvir (MK-3682): A Green and Sustainable Process for Preparing Penultimate 2′-Deoxy-α-2′-Chloro-β-2′-Methyluridine-Reference-Cited by-同舟云学术

Manufacturing Process Development for Uprifosbuvir (MK-3682): A Green and Sustainable Process for Preparing Penultimate 2′-Deoxy-α-2′-Chloro-β-2′-Methyluridine

Published:2022-08-16 Issue:9 Volume:26 Page:2728-2738
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Maligres Peter E.¹^ORCID,Peng Feng¹^ORCID,Calabria Ralph¹,Campeau Louis-Charles¹^ORCID,Chen Wenyong¹,Dormer Peter G.¹,Green Meredith¹,He Cyndi Qixin¹^ORCID,Hyde Alan M.¹^ORCID,Klapars Artis¹,Larsen Mona Utne¹,Limanto John¹,Liu Guiquan²,Liu Yizhou¹^ORCID,Moment Aaron¹^ORCID,Nowak Timothy¹,Ruck Rebecca T.¹^ORCID,Shevlin Michael¹^ORCID,Song Zhiguo Jake¹^ORCID,Tan Lushi¹,Tong Weidong¹^ORCID,Waldman Jacob H.¹,Ye Honglin²,Zhao Ralph¹^ORCID,Zhou George¹,Zompa Michael A.¹^ORCID,Zultanski Susan L.¹

Affiliation:

1. Process Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States

2. Shanghai SynTheAll Pharmaceutical Co. Ltd., 9 Yuegong Road, Jinshan District, Shanghai 201507, China

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.2c00191

Reference43 articles.

1. Approved Antiviral Drugs over the Past 50 Years

2. A 40-Year Journey in Search of Selective Antiviral Chemotherapy*

3. Broad-Spectrum Antiviral Strategies and Nucleoside Analogues

4. The discovery of IDX21437: Design, synthesis and antiviral evaluation of 2′-α-chloro-2′-β-C-methyl branched uridine pronucleotides as potent liver-targeted HCV polymerase inhibitors

5. https://www.who.int/news-room/fact-sheets/detail/hepatitis-c. See Zoratti, M. Web Annex 3.1. Adult hepatitis C virus treatment systematic review. In Guidelines for the care and treatment of persons diagnosed with chronic hepatitis C virus infection, 2018 https://apps.who.int/iris/bitstream/handle/10665/277215/WHO-CDS-HIV-18.36-eng.pdf.

Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Advancements in hydrochlorination of alkenes;Beilstein Journal of Organic Chemistry;2024-04-15

2. Biocatalytic Friedel‐Crafts Reactions;ChemCatChem;2022-08-24