Advancing Scalable Chemistry toward Novel CELMoDs: Process Development for the Synthesis of CC-90009-Reference-Cited by-同舟云学术

Advancing Scalable Chemistry toward Novel CELMoDs: Process Development for the Synthesis of CC-90009

Published:2022-09-01 Issue:9 Volume:26 Page:2739-2748
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Zacuto Michael J.¹^ORCID,Williams Michael J.¹,Zhang Weihong¹,Han Jianxin¹,Beauchamps Marie G.¹,Kothare Mohit¹,Konnecke William¹,Smith Randi¹,Feigelson Gregg¹

Affiliation:

1. Chemical Process Development, Bristol Myers Squibb, 556 Morris Avenue, Summit, New Jersey 07901, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.2c00199

Reference17 articles.

1. CC-90009: A Cereblon E3 Ligase Modulating Drug That Promotes Selective Degradation of GSPT1 for the Treatment of Acute Myeloid Leukemia

2. Manufacturing Synthesis of 5-Substituted Phthalides

3. Efficient Synthesis of 1,4-Diaryl-5-methyl-1,2,3-triazole, A Potential mGluR1 Antagonist, and the Risk Assessment Study of Arylazides

4. b Boyd, A.; Fielding, M. R.; Ford, J. G.; Frodsham, L.; Golden, M. D.; Leslie, K. W.; McKeeber-Abbas, B.; Tomlin, P. Process for Making a Metabotropic Glutamate receptor Positive Allosteric Modulator – 874. WO 2011/084098.

5. Synthesis and sar studies for the inhibition of tnf-α production. part 2. 2-[3-(cyclopentyloxy)-4-methoxyphenyl]-substituted-1 -isoindolinone derivatives

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