Applications of TiCl3 as a Diagnostic Reagent for the Detection of Nitro- and N-Oxide-Containing Compounds as Potentially Mutagenic Impurities Using Ultrahigh-Performance Liquid Chromatography Coupled with High-Resolution Mass Spectrometry-Reference-Cited by-同舟云学术

Applications of TiCl3 as a Diagnostic Reagent for the Detection of Nitro- and N-Oxide-Containing Compounds as Potentially Mutagenic Impurities Using Ultrahigh-Performance Liquid Chromatography Coupled with High-Resolution Mass Spectrometry

Published:2015-12-18 Issue:1 Volume:20 Page:59-64
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Yang Rong-Sheng¹,Beard Adam¹,Sheng Huaming¹,Zhang Li-Kang¹,Helmy Roy¹

Affiliation:

1. Department of Process and Analytical Chemistry, Merck & Co. Inc., Rahway, New Jersey 07065, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.5b00312

Reference26 articles.

1. Ultimate Carcinogenic Metabolites from Aromatic and Heterocyclic Aromatic Amines: A Computational Study in Relation to Their Mutagenic Potency

2. Risk Assessment of Genotoxic Impurities in Marketed Compounds Administered over a Short-Term Duration: Applications to Oncology Products and Implications for Impurity Control Limits

3. Special Feature Section: Potential Genotoxic Impurities

4. Control of Genotoxic Impurities in Active Pharmaceutical Ingredients: A Review and Perspective

5. Removal of Electrophilic Potential Genotoxic Impurities Using Nucleophilic Reactive Resins

Cited by 9 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Highly sensitive LC‐MS method for stereochemical quality control of a pharmaceutical drug substance intermediate;Chirality;2022-03-16

2. Characterization of Protonated Substituted Ureas by Using Diagnostic Gas-Phase Ion-Molecule Reactions Followed by Collision-Activated Dissociation in Tandem Mass Spectrometry Experiments;Analytical Chemistry;2021-05-24

3. Identification of Protonated Primary Carbamates by Using Gas-Phase Ion–Molecule Reactions Followed by Collision-Activated Dissociation in Tandem Mass Spectrometry Experiments;Organic Process Research & Development;2019-05-28

4. Enrichment of Relevant Oxidative Degradation Products in Pharmaceuticals With Targeted Chemoselective Oxidation;Journal of Pharmaceutical Sciences;2019-04

5. Association of Metronidazole with Cancer: A Potential Risk Factor or Inconsistent Deductions?;Current Drug Metabolism;2018-10-02