Identification of Protonated Primary Carbamates by Using Gas-Phase Ion–Molecule Reactions Followed by Collision-Activated Dissociation in Tandem Mass Spectrometry Experiments-Reference-Cited by-同舟云学术

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Identification of Protonated Primary Carbamates by Using Gas-Phase Ion–Molecule Reactions Followed by Collision-Activated Dissociation in Tandem Mass Spectrometry Experiments

Published:2019-05-28 Issue:6 Volume:23 Page:1159-1166
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Niyonsaba Edouard¹^ORCID,Easton Mckay W.¹^ORCID,Liu Judy K.Y.¹,Yu Zaikuan¹,Sheng Huaming²,Kong John Y.²,Zhang Zhoupeng³,Easterling Leah F.¹,Milton Jacob¹,Kenttämaa Hilkka I.¹^ORCID

Affiliation:

1. Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States

2. Department of Analytical Research & Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States

3. Department of Pharmacokinetics, Pharmacodynamics & Drug Metabolism, Merck & Co., Inc., West Point, Pennsylvania 19486, United States

Funder

Merck Sharp and Dohme

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.9b00080

Reference32 articles.

1. Risk Assessment of Genotoxic Impurities in Marketed Compounds Administered over a Short-Term Duration: Applications to Oncology Products and Implications for Impurity Control Limits

2. Removal of Electrophilic Potential Genotoxic Impurities Using Nucleophilic Reactive Resins

3. Quantitative assessment of cumulative carcinogenic risk for multiple genotoxic impurities in a new drug substance

4. Application of Quality by Design Principles to Support Development of a Control Strategy for the Control of Genotoxic Impurities in the Manufacturing Process of a Drug Substance

5. Potentially mutagenic impurities: Analysis of structural classes and carcinogenic potencies of chemical intermediates in pharmaceutical syntheses supports alternative methods to the default TTC for calculating safe levels of impurities

Cited by 4 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Differentiation of the Aziridine Functionality from Related Functional Groups in Protonated Analytes by Using Selective Ion-Molecule Reactions Followed by Collision-Activated Dissociation in a Linear Quadrupole Ion Trap Mass Spectrometer;The Journal of Organic Chemistry;2023-06-23

2. Differentiation of Protonated Sulfonate Esters from Isomeric Sulfite Esters and Sulfones by Gas-Phase Ion–Molecule Reactions Followed by Diagnostic Collision-Activated Dissociation in Tandem Mass Spectrometry Experiments;Analytical Chemistry;2022-05-25

3. Determination of the compound class and functional groups in protonated analytes via diagnostic gas‐phase ion‐molecule reactions;Mass Spectrometry Reviews;2021-08-26

4. Characterization of Protonated Substituted Ureas by Using Diagnostic Gas-Phase Ion-Molecule Reactions Followed by Collision-Activated Dissociation in Tandem Mass Spectrometry Experiments;Analytical Chemistry;2021-05-24

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