Differentiation of the Aziridine Functionality from Related Functional Groups in Protonated Analytes by Using Selective Ion-Molecule Reactions Followed by Collision-Activated Dissociation in a Linear Quadrupole Ion Trap Mass Spectrometer-Reference-Cited by-同舟云学术

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Differentiation of the Aziridine Functionality from Related Functional Groups in Protonated Analytes by Using Selective Ion-Molecule Reactions Followed by Collision-Activated Dissociation in a Linear Quadrupole Ion Trap Mass Spectrometer

Published:2023-06-23 Issue:13 Volume:88 Page:8865-8873
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Anyaeche Ruth O.¹,Alzarieni Kawthar Z.²,Kumar Rashmi¹,Milton Jacob R.¹,Kaur Jaskiran¹^ORCID,Sheng Huaming³^ORCID,Kenttämaa Hilkka I.¹^ORCID

Affiliation:

1. Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States

2. Faculty of Pharmacy, Department of Medicinal Chemistry and Pharmacognosy, Jordan University of Science and Technology, Irbid 22110, Jordan

3. Merck & Co., Inc., Rahway, New Jersey 07065, United States

Funder

National Science Foundation

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.joc.3c00655

Reference21 articles.

1. Mutagenicity of ethyleneimine

2. Risk Assessment of Genotoxic Impurities in Marketed Compounds Administered over a Short-Term Duration: Applications to Oncology Products and Implications for Impurity Control Limits

3. Structure-based thresholds of toxicological concern (TTC): guidance for application to substances present at low levels in the diet

4. Analytical control strategies for mutagenic impurities: Current challenges and future opportunities?

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