Continuous Selective Hydrogenation of Refametinib Iodo-nitroaniline Key Intermediate DIM-NA over Raney Cobalt Catalyst at kg/day Scale with Online UV–Visible Conversion Control-Reference-Cited by-同舟云学术

Continuous Selective Hydrogenation of Refametinib Iodo-nitroaniline Key Intermediate DIM-NA over Raney Cobalt Catalyst at kg/day Scale with Online UV–Visible Conversion Control

Published:2017-05-04 Issue:5 Volume:21 Page:705-714
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Said Mourad Ben¹,Baramov Todor²³,Herrmann Tanja¹,Gottfried Michael¹,Hassfeld Jorma²,Roggan Stefan²

Affiliation:

1. Engineering & Technology, Bayer AG, D-51368 Leverkusen, Germany

2. Pharmaceuticals Division, Bayer AG, D-42096 Wuppertal, Germany

3. Leibniz-Institut für Katalyse e.V. (LIKAT), Albert-Einstein-Str. 29a, D-18059 Rostock, Germany

Funder

FP7 Joint Technology Initiatives

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.7b00039

Reference59 articles.

1. Multiphase reactors – revisited

2. Kontinuierliche Durchflussverfahren: ein Werkzeug für die sichere Synthese von pharmazeutischen Wirkstoffen

3. Angew. Chem., Int. Ed. 2015, 54, 6688. 10.1002/anie.201409318

4. Continuous Flow Synthesis. A Pharma Perspective

5. Microreactor Technology: A Revolution for the Fine Chemical and Pharmaceutical Industries?

Cited by 18 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Practical synthesis of tetrahydrofolate by highly efficient catalytic hydrogenation in continuous flow;Journal of Flow Chemistry;2024-02-16

2. Organic synthesis in flow mode by selective liquid-phase hydrogenation over heterogeneous non-noble metal catalysts;Organic & Biomolecular Chemistry;2024

3. Multiphasic Continuous‐Flow Reactors for Handling Gaseous Reagents in Organic Synthesis: Enhancing Efficiency and Safety in Chemical Processes;Angewandte Chemie International Edition;2023-12-27

4. Multiphasic Continuous‐Flow Reactors for Handling Gaseous Reagents in Organic Synthesis: Enhancing Efficiency and Safety in Chemical Processes;Angewandte Chemie;2023-12-27

5. Fixed Bed Continuous Hydrogenations in Trickle Flow Mode: A Pharmaceutical Industry Perspective;Organic Process Research & Development;2022-06-14