Affiliation:
1. Flow Chemistry Group van't Hoff Institute for Molecular Sciences (HIMS) Universiteit van Amsterdam (UvA) Science Park 904 1098 XH Amsterdam The Netherlands
Abstract
AbstractThe use of reactive gaseous reagents for the production of active pharmaceutical ingredients (APIs) remains a scientific challenge due to safety and efficiency limitations. The implementation of continuous‐flow reactors has resulted in rapid development of gas‐handling technology because of several advantages such as increased interfacial area, improved mass‐ and heat transfer, and seamless scale‐up. This technology enables shorter and more atom‐economic synthesis routes for the production of pharmaceutical compounds. Herein, we provide an overview of literature from 2016 onwards in the development of gas‐handling continuous‐flow technology as well as the use of gases in functionalization of APIs.
Funder
HORIZON EUROPE European Research Council