The Evolving State of Continuous Processing in Pharmaceutical API Manufacturing: A Survey of Pharmaceutical Companies and Contract Manufacturing Organizations

Author:

McWilliams J. Christopher1ORCID,Allian Ayman D.2,Opalka Suzanne M.3,May Scott A.4ORCID,Journet Michel5,Braden Timothy M.4ORCID

Affiliation:

1. Chemical Research and Development, Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States

2. Department of Pivotal Drug Substance Technologies, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320, United States

3. Chemical Process Development, Biogen Idec, 115 Broadway, Cambridge, Massachusetts 02142, United States

4. Small Molecule Design and Development, Eli Lilly and Company, Indianapolis, Indiana 46285, United States

5. API Chemistry, GSK, 709 Swedeland Road, UW2810, P.O. Box 1539, King of Prussia, Pennsylvania 19406, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Reference118 articles.

1. Continuous flow technology vs. the batch-by-batch approach to produce pharmaceutical compounds

2. Flow chemistry, continuous processing, and continuous manufacturing: A pharmaceutical perspective

3. bGarguilo, L. Novartis And The Arrival Of The Continuous Manufacturing Facility. OUTSOURCED PHARMA [Online], 2017. https://www.outsourcedpharma.com/doc/novartis-and-the-arrival-of-the-continuous-manufacturing-facility-0001 (accessed July 27, 2018).

4. cTaylor, P. GSK and Pfizer team up on continuous manufacturing project. In-Pharma Technologist.com [Online], 2015. https://www.in-pharmatechnologist.com/Article/2015/11/03/GSK-and-Pfizer-team-up-on-continuous-manufacturing-project?utm_source=copyright&utm_medium=OnSite&utm_campaign=copyright (accessed July 27, 2018).

5. d Eli Lilly to invest €35m in Kinsale plant. The Irish Times April, 2016, 2016.

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