A Facile, Six-Step Process for the Synthesis of (3S,5S)-3-Isopropyl-5-((2S,4S)-4-isopropyl-5-oxo-tetrahydrofuran-2-yl)-2-oxopyrrolidine-1-carboxylic Acid tert-Butyl Ester, The Key Synthetic Intermediate of Aliskiren-Reference-Cited by-同舟云学术

A Facile, Six-Step Process for the Synthesis of (3S,5S)-3-Isopropyl-5-((2S,4S)-4-isopropyl-5-oxo-tetrahydrofuran-2-yl)-2-oxopyrrolidine-1-carboxylic Acid tert-Butyl Ester, The Key Synthetic Intermediate of Aliskiren

Published:2015-06-03 Issue:6 Volume:19 Page:611-617
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Pan Xianhua¹,Xu Siyao¹,Huang Rui¹,Yu Wansheng¹,Liu Feng¹

Affiliation:

1. School of Perfume and Aroma Technology, Shanghai Institute of Technology, 100 Haiquan Rd, Shanghai, 201418, P. R. China

Funder

National Natural Science Foundation of China

Shanghai Engineering Technology Research Center of Fragrance and Flavor

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.5b00009

Reference33 articles.

1. The Renin-Angiotensin System

2. Goeschke, R.; Rasseti, V.; Cohen, N. C.; Rahuel, J.; Grutter, M.; Stutz, S.; Fuhrer, W.; Wood, J.; Maibaum, J.15th Int. Symposium Med. Chem., 6–10 September, Edinburgh, 1998, Abst. 229.

3. Maibaum, J.15th Int. Symposium Med. Chem., Edinburgh, September 6–10, 1998; Abst. 230, 231.

4. Structure-based drug design: the discovery of novel nonpeptide orally active inhibitors of human renin

5. aGöschke, R.; Rigollier, P.; Jürgen, K. M.3,5-Disubstituted tetrahydrofuran-2-ones. US 5606078, 1995.

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