Synthesis of a Crizotinib Intermediate via Highly Efficient Catalytic Hydrogenation in Continuous Flow-Reference-Cited by-同舟云学术

Synthesis of a Crizotinib Intermediate via Highly Efficient Catalytic Hydrogenation in Continuous Flow

Published:2020-09-29 Issue:10 Volume:24 Page:2252-2259
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Xu Feng¹,Chen Jianli¹,Xie Xiaoxuan¹,Cheng Pengfei¹,Yu Zhiqun¹^ORCID,Su Weike²^ORCID

Affiliation:

1. National Engineering Research Center for Process Development of Active Pharmaceutical Ingredients, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, P. R. China

2. Key Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, P. R. China

Funder

Natural Science Foundation of Zhejiang Province

Zhejiang Province

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.0c00302

Reference36 articles.

1. Fit-for-Purpose Development of the Enabling Route to Crizotinib (PF-02341066)

2. Chava, S.; Gorantla, A. S. R.; Indukuri, V. S. K.; Moturu, M. V. R. K.; Karuturi, R. V. V. A process for the preparation of crizotinib or an acid addition salt thereof. WO 2015107553 A2, 2015.

3. Gong, F.; Li, X. L.; Zhao, R.; Zhang, X. Q.; Xu, X. H.; Liu, X. J.; Xiao, D. M.; Han, Y. X. Pyridine substituded 2-aminopyridine protein kinase inhibitor crystal. WO 2017016514 A1, 2017.

4. Recent Advances in the Reduction of Nitro Compounds by Heterogenous Catalysts

5. Rapid reduction of heteroaromatic nitro groups using catalytic transfer hydrogenation with microwave heating

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