A Design of Experiments Approach to a Robust Final Deprotection and Reactive Crystallization of IPI-926, A Novel Hedgehog Pathway Inhibitor-Reference-Cited by-同舟云学术

A Design of Experiments Approach to a Robust Final Deprotection and Reactive Crystallization of IPI-926, A Novel Hedgehog Pathway Inhibitor

Published:2015-09-10 Issue:11 Volume:19 Page:1693-1702
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Martinot Theodore A.¹,Austad Brian C.¹,Côté Alexandre¹,Depew Kristopher M.¹,Genov Daniel¹,Grenier Louis¹,Helble Joseph¹,Lescarbeau Andre¹,Nair Somarajan¹,Trudeau Martin¹,White Priscilla¹,Yu Lin-Chen¹

Affiliation:

1. Infinity Pharmaceuticals, 784 Memorial Drive, Cambridge, Massachusetts 02139, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.5b00214

Reference9 articles.

1. Discovery of a Potent and Orally Active Hedgehog Pathway Antagonist (IPI-926)

2. Optimal Design of Experiments

3. JMP (SAS Institute, Inc.) was used to create all DoE models. Version 11.1.1 was used for all outputs. Models were refined and optimized using a Standard Least Squares approach, to eliminate terms that did not contribute significantly to the model (p> 0.05, starting with the highest values) or using a Stepwise approach, with the same criterion. All data tables and analyses are available in theSupporting Informationsection.

4. Highly Functionalised Sulfur-Based Silica Scavengers for the Efficient Removal of Palladium Species from Active Pharmaceutical Ingredients

5. Removal of Heavy Metals from Organic Reaction Mixtures: Preparation and Application of Functionalized Resins

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