Evolution of a Green and Sustainable Manufacturing Process for Belzutifan: Part 1─Process History and Development Strategy-Reference-Cited by-同舟云学术

Evolution of a Green and Sustainable Manufacturing Process for Belzutifan: Part 1─Process History and Development Strategy

Published:2024-02-05 Issue:2 Volume:28 Page:404-412
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

DiRocco Daniel A.¹^ORCID,Zhong Yong-Li¹,Le Diane N.¹^ORCID,McCann Scott D.¹^ORCID,Hethcox J. Caleb¹^ORCID,Kim Jungchul¹^ORCID,Kolev Joshua N.¹^ORCID,Kosjek Birgit¹,Dalby Stephen M.¹,McMullen Jonathan P.¹^ORCID,Gangam Rekha²,Morris William J.¹^ORCID

Affiliation:

1. Process Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States

2. Analytical Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.3c00408

Reference25 articles.

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2. Dixon, D. D.; Stengel, P. J.; Wang, B. HIF-2-A Inhibitor Polymorphs. WO 2016145236 A1, September 15, 2016.

3. Manufacturing Process Development for Belzutifan, Part 1: A Concise Synthesis of the Indanone Starting Material

4. Manufacturing Process Development for Belzutifan, Part 2: A Continuous Flow Visible-Light-Induced Benzylic Bromination

5. Manufacturing Process Development for Belzutifan, Part 3: Completing a Streamlined Through-Process with a Safe and Scalable Oxidation

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