Development of a Green and Sustainable Manufacturing Process for Gefapixant Citrate (MK-7264). Part 6: Development of an Improved Commercial Salt Formation Process-Reference-Cited by-同舟云学术

Development of a Green and Sustainable Manufacturing Process for Gefapixant Citrate (MK-7264). Part 6: Development of an Improved Commercial Salt Formation Process

Published:2020-10-23 Issue:11 Volume:24 Page:2498-2504
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Maloney Kevin M.¹^ORCID,Zhang Si-Wei¹^ORCID,Mohan Anne E.¹,Lee Alfred Y.¹^ORCID,Larpent Patrick¹,Ren Hong¹^ORCID,Humphrey Guy R.¹^ORCID,Desmond Richard¹,DiBenedetto Michael¹,Liu Wenjun¹,Lee Ivan H.¹,Sirota Eric¹,Di Maso Michael J.¹^ORCID,Alwedi Embarek¹^ORCID,Song Siqing¹,Chang Hsieh Yao D.¹

Affiliation:

1. Department of Process Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.0c00260

Reference10 articles.

1. In particular, Q11: Development and Manufacture of Drug Substances (Chemical Entities and Biotechnological/Biological Entities), Version Dated May 1st 2012. ICH Quality Guidelines are available online at https://www.ich.org/page/quality-guidelines.

2. Crystallization in the pharmaceutical and bioprocessing industries

3. Crystal Polymorphism in Chemical Process Development

4. Update on novel purinergic P2X3 and P2X2/3 receptor antagonists and their potential therapeutic applications

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