Development of a Green and Sustainable Manufacturing Process for Gefapixant Citrate (MK-7264). Part 6: Development of an Improved Commercial Salt Formation Process
Author:
Affiliation:
1. Department of Process Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Physical and Theoretical Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.0c00260
Reference10 articles.
1. In particular, Q11: Development and Manufacture of Drug Substances (Chemical Entities and Biotechnological/Biological Entities), Version Dated May 1st 2012. ICH Quality Guidelines are available online at https://www.ich.org/page/quality-guidelines.
2. Crystallization in the pharmaceutical and bioprocessing industries
3. Crystal Polymorphism in Chemical Process Development
4. Update on novel purinergic P2X3 and P2X2/3 receptor antagonists and their potential therapeutic applications
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