Development of a Green and Sustainable Manufacturing Process for Gefapixant Citrate (MK-7264) Part 2: Development of a Robust Process for Phenol Synthesis-Reference-Cited by-同舟云学术

Development of a Green and Sustainable Manufacturing Process for Gefapixant Citrate (MK-7264) Part 2: Development of a Robust Process for Phenol Synthesis

Published:2020-10-16 Issue:11 Volume:24 Page:2453-2461
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Peng Feng¹^ORCID,Humphrey Guy R.¹^ORCID,Maloney Kevin M.¹^ORCID,Lehnherr Dan¹^ORCID,Weisel Mark¹,Lévesque Francois¹^ORCID,Naber John R.¹^ORCID,Brunskill Andrew P. J.¹,Larpent Patrick¹,Zhang Si-Wei¹^ORCID,Lee Alfred Y.¹^ORCID,Arvary Rebecca A.¹,Lee Claire H.¹,Bishara Daniel¹,Narsimhan Karthik¹,Sirota Eric¹,Whittington Michael¹

Affiliation:

1. Small Molecule Process Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.0c00241

Reference75 articles.

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2. Identification and SAR of novel diaminopyrimidines. Part 2: The discovery of RO-51, a potent and selective, dual P2X3/P2X2/3 antagonist for the treatment of pain

3. The intermediate for this transformation is styrene, generated in situ via elimination of water.

4. ortho-Directed metallation in the regiocontrolled synthesis of enantiopure 2- and/or 3-substituted (S)S-(p-tolylsulfinyl)-1,4-benzoquinones

5. Synthesis of (±)- and (+)-perovskone

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