A Convergent Continuous Multistep Process for the Preparation of C4-Oxime-Substituted Thiazoles

Author:

Godineau Edouard1ORCID,Battilocchio Claudio12,Lehmann Matthias1,Ley Steven V.2ORCID,Labes Ricardo2ORCID,Birnoschi Letitia2,Subramanian Srinivas3,Prasanna C. S.3,Gorde Amol3,Kalbagh Mahesh3,Khade Vivek3,Scherrer Anton1,O’Sullivan Anthony C.1ORCID

Affiliation:

1. Syngenta Crop Protection, Process Research, Schaffhauserstrasse 101, CH-4332 Stein, Switzerland

2. Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, U.K.

3. Syngenta Research and Technology Centre, Santa Monica Works, Corlim, Goa-403110, India

Funder

Engineering and Physical Sciences Research Council

Syngenta International

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Reference27 articles.

1. De Bruyn, M. F. L.; Van Lommen, G. R. E.; Lutz, W. R. Preparation and testing of 1,5-disubstituted 1H-imidazoles as herbicides. Patent EP289066A1, 1988.

2. Von Deyn, W.; McLaughlin, M. J.; Gockel, B.; Koerber, K.; Dietz, J.; Pohlman, M.; Kojima, K. N-substituted imino heterocyclic compounds for combating invertebrate pests. WO2015124606A1, 2015.

3. Cristau, P.; Rahn, N.; Tsuchiya, T.; Wachendorff-Neumann, U.; Voerste, A.; Benting, J. Thiazolyl oxime ethers and hydrazones as crop protection agents. Patent WO2010066353A1, 2010.

4. Shioda, T.; Yoshimoto, Y. Preparation of phenyltetrazolinone derivatives as agrochemical fungicides. Patent WO2015060461A1, 2015.

5. Application of oxime-diversification to optimize ligand interactions within a cryptic pocket of the polo-like kinase 1 polo-box domain

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