An Improved and Enantioselective Preparation of the Telaprevir Bicyclic [3.3.0] Proline Intermediate and Reuse of Unwanted Enantiomer-Reference-Cited by-同舟云学术

An Improved and Enantioselective Preparation of the Telaprevir Bicyclic [3.3.0] Proline Intermediate and Reuse of Unwanted Enantiomer

Published:2016-01-12 Issue:2 Volume:20 Page:320-324
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Liu Lin-Wei¹²,Wang Fei-Ying¹,Tian Fang¹,Peng Lin¹,Wang Li-Xin¹

Affiliation:

1. Key Laboratory of Asymmetric Synthesis & Chirotechnology of Sichuan Province, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, P. R. China

2. University of Chinese Academy of Sciences, Beijing 100039, P. R. China

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.5b00345

Reference41 articles.

1. World Health Organization. Health topics: hepatitis, 2011.

2. The Prevalence of Hepatitis C Virus Infection in the United States, 1999 through 2002

3. HCV drug discovery aimed at viral eradication

4. Telaprevir: A Novel NS3/4 Protease Inhibitor for the Treatment of Hepatitis C

5. aTanoury, G. J.; Chen, M.; Cochran, J. E.Processes and intermediates. WO 2007022459, 2007.

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