Development of a Scalable Lanthanide Halide/Quaternary Ammonium Salt System for the Nucleophilic Addition of Grignard Reagents to Carbonyl Groups and Application to the Synthesis of a Remdesivir Intermediate-Reference-Cited by-同舟云学术

Development of a Scalable Lanthanide Halide/Quaternary Ammonium Salt System for the Nucleophilic Addition of Grignard Reagents to Carbonyl Groups and Application to the Synthesis of a Remdesivir Intermediate

Published:2021-08-05 Issue: Volume: Page:
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Stevens Andrew C.¹^ORCID,Brak Katrien²,Bremner W. Stacy¹,Brown Angela M.³,Chtchemelinine Andrei²,Heumann Lars²,Kerschen James A.³,Subotkowski Witold³,Vieira Tiago¹^ORCID,Wolfe Lydia C.²,Xu Boran¹,Yu Chia-Yun²

Affiliation:

1. Gilead Alberta ULC, 1021 Hayter Road, Edmonton, Alberta T6S 1A1, Canada

2. Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States

3. J-Star Research Inc., 3001 Hadley Road #3, South Plainsfield, New Jersey 07080, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.1c00191

Reference31 articles.

1. Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys