Affiliation:
1. Anhui University Chemistry & Chemical Engineering Anhui University 230601 Hefei Anhui P. R. China
2. Hefei National Laboratory for Physical Sciences at the Microscale Center for Excellence in Molecular Synthesis of CAS Department of Chemistry University of Science and Technology of China 230601 Hefei Anhui P. R. China
3. Nature Pharmaceutical (Anhui) Co. Ltd. 4th floor, 6# building, 8# Huangguan Road, Anqing Hi-Tech Development District 246000 Anqing Anhui province P. R. China
Abstract
AbstractA direct and regioselective lithiation was realized on N‐Boc‐pyrrolo[2,1‐f][1,2,4]triazine, simply utilizing the distinct sigma‐acidity on C‐9. Starting from this enabling discovery, C‐glycoside formation, cyanation, and global deprotection steps constitute one of the most efficient syntheses of GS‐441524. Furthermore, transient protection was applied on GS‐441524 with phenyl boronic acid, which facilitated a powerful one‐pot synthesis of remdesivir.
Funder
National Natural Science Foundation of China
Subject
Organic Chemistry,Physical and Theoretical Chemistry
Cited by
1 articles.
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