New Perspectives on Antimicrobial Agents: Remdesivir Treatment for COVID-19-Reference-Cited by-同舟云学术

New Perspectives on Antimicrobial Agents: Remdesivir Treatment for COVID-19

Published:2020-12-16 Issue:1 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Aleissa Muneerah M.¹,Silverman Emily A.²,Paredes Acosta Luisa M.³⁴,Nutt Cameron T.³⁴,Richterman Aaron⁵,Marty Francisco M.²³⁴^ORCID

Affiliation:

1. Department of Pharmacy, Brigham and Women’s Hospital, Boston, Massachusetts, USA

2. Division of Infectious Diseases, Brigham and Women’s Hospital and Dana-Farber Cancer Institute, Boston, Massachusetts, USA

3. Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, USA

4. Harvard Medical School, Boston, Massachusetts, USA

5. Division of Infectious Diseases, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA

Abstract

Remdesivir was recently approved by the Food and Drug Administration for the treatment of hospitalized patients with coronavirus disease 2019 (COVID-19). Remdesivir is the prodrug of an adenosine analogue that inhibits viral replication of several RNA virus families, including Coronaviridae . Preclinical data in animal models of coronavirus diseases, including COVID-19, have demonstrated that early treatment with remdesivir leads to improved survival, decreased lung injury, and decreased levels of viral RNA.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01814-20

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