Kinetic and Mechanistic Investigations to Enable a Key Suzuki Coupling for Sotorasib Manufacture─What a Difference a Base Makes-Reference-Cited by-同舟云学术

Kinetic and Mechanistic Investigations to Enable a Key Suzuki Coupling for Sotorasib Manufacture─What a Difference a Base Makes

Published:2022-12-19 Issue:1 Volume:27 Page:198-205
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Murray James I.¹^ORCID,Zhang Liang²^ORCID,Simon Adam³,Silva Elipe Maria V.⁴^ORCID,Wei Carolyn S.¹,Caille Seb¹^ORCID,Parsons Andrew T.²^ORCID

Affiliation:

1. Pivotal and Commercial Synthetics, Drug Substance Technologies, Process Development, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320, United States

2. Pivotal and Commercial Synthetics, Drug Substance Technologies, Process Development,Amgen Inc., 360 Binney Street, Cambridge, Massachusetts 02142, United States

3. Center for Research Acceleration by Digitalization, Research & Development, Drug Substance Technologies, Process Development, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320, United States

4. Pivotal Attribute Sciences, Drug Substance Technologies, Process Development, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.2c00332

Reference49 articles.

1. ras GENES

2. RAS Proteins and Their Regulators in Human Disease

3. KRASG12C Inhibition with Sotorasib in Advanced Solid Tumors

4. The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity

5. Development of a Commercial Manufacturing Process for Sotorasib, a First-in-Class KRAS^G12C Inhibitor

Cited by 10 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Understanding and Controlling Reactivity Patterns of Pd₁@C₃N₄-Catalyzed Suzuki–Miyaura Couplings;ACS Catalysis;2024-08-07

2. Investigating the Origin of Epimerization Attenuation during Pd-Catalyzed Cross-Coupling Reactions;ACS Catalysis;2024-08-03

3. Cryogen‐free 400‐MHz nuclear magnetic resonance spectrometer as a versatile tool for pharmaceutical process analytical technology;Magnetic Resonance in Chemistry;2024-02-18

4. First atroposelective Chan–Lam coupling for the synthesis of C–N linked biaryls;Chemical Communications;2024

5. Electrosynthesis of iminophosphoranes and applications in nickel catalysis;Chemical Science;2024