Synthesis of Mavatrep: A Potent Antagonist of Transient Receptor Potential Vanilloid-1-Reference-Cited by-同舟云学术

Synthesis of Mavatrep: A Potent Antagonist of Transient Receptor Potential Vanilloid-1

Published:2015-10-15 Issue:11 Volume:19 Page:1774-1783
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Wells Kenneth M.¹,Mehrman Steven J.¹,Abdel-Magid Ahmed F.¹,Ferraro Caterina¹,Scott Lorraine¹,Zhong Hua Marlon¹,Teleha Christopher A.¹,Ballentine Scott¹,Li Xun¹,Russell Ronald K.¹,Spink Jan M.¹,Diamond Craig¹,Youells Scott¹,Zhang Yongzheng¹,Tsay Fuh-Rong¹,Cesco-Cancia Sergio¹,Manzo Stephen M.¹,Beauchamp Derek A.¹

Affiliation:

1. Janssen Research and Development, LLC, Welsh & McKean Roads, Spring House, Pennsylvania 19477-0776, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.5b00271

Reference30 articles.

1. TRPing the switch on pain: an introduction to the chemistry and biology of capsaicin and TRPV1

2. The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept

3. Benzo[d]imidazole Transient Receptor Potential Vanilloid 1 Antagonists for the Treatment of Pain: Discovery of trans-2-(2-{2-[2-(4-Trifluoromethyl-phenyl)-vinyl]-1H-benzimidazol-5-yl}-phenyl)-propan-2-ol (Mavatrep)

4. bPlayer, M. R.; Dax, S. L.; Parsons, W. H.; Brandt, M. R.; Calvo, R. R.; Patel, S.; Liu, J.; Cheung, W. S.; Jetter, M. C.; Lee, Y.K.; Youngman, M. A.; Pan, W.; Wells, K. M.; Beauchamp, D. A.Benzimidazole Modulators of VR1. U.S. Patent US 2007259936, 2007.

5. Regiospecific Glycosidation of Unprotected Sugars via Arylboronic Activation

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