Benzo[d]imidazole Transient Receptor Potential Vanilloid 1 Antagonists for the Treatment of Pain: Discovery of trans-2-(2-{2-[2-(4-Trifluoromethyl-phenyl)-vinyl]-1H-benzimidazol-5-yl}-phenyl)-propan-2-ol (Mavatrep)-Reference-Cited by-同舟云学术

Benzo[d]imidazole Transient Receptor Potential Vanilloid 1 Antagonists for the Treatment of Pain: Discovery of trans-2-(2-{2-[2-(4-Trifluoromethyl-phenyl)-vinyl]-1H-benzimidazol-5-yl}-phenyl)-propan-2-ol (Mavatrep)

Published:2015-04-15 Issue:9 Volume:58 Page:3859-3874
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Parsons William H.¹,Calvo Raul R.¹,Cheung Wing¹,Lee Yu-Kai¹,Patel Sharmila¹,Liu Jian¹,Youngman Mark A.¹,Dax Scott L.¹,Stone Dennis¹,Qin Ning¹,Hutchinson Tasha¹,Lubin Mary Lou¹,Zhang Sui-Po¹,Finley Michael¹,Liu Yi¹,Brandt Michael R.¹,Flores Christopher M.¹,Player Mark R.¹

Affiliation:

1. Janssen Research & Development, Welsh and McKean Roads, Spring House, Pennsylvania 19477, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.5b00132

Reference37 articles.

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3. Dose-dependent pain and mechanical hyperalgesia in humans after intradermal injection of capsaicin