Development of a Commercial Flow Barbier Process for a Pharmaceutical Intermediate-Reference-Cited by-同舟云学术

Development of a Commercial Flow Barbier Process for a Pharmaceutical Intermediate

Published:2017-02-16 Issue:3 Volume:21 Page:317-326
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Braden Timothy M.¹^ORCID,Johnson Martin D.¹,Kopach Michael E.¹,McClary Groh Jennifer¹,Spencer Richard D.²,Lewis Jeffrey³,Heller Michael R.³,Schafer John P.³,Adler Jonathan J.³

Affiliation:

1. Small Molecule Design and Development, Eli Lilly and Company, Indianapolis, Indiana 46285, United States

2. Eli Lilly SA, Dunderrow, Kinsale, County Cork, Ireland

3. D&M Continuous Solutions, LLC, Indianapolis, Indiana 46237, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.6b00373

Reference11 articles.

1. Process Research on [(2S)-(3-Fluorophenyl)-(1S)-(5-oxotetrahydrofuran- 2-yl)ethyl]carbamic Acid tert-Butyl Ester, a Lactone Intermediate for an Aspartyl Protease Inhibitor

2. Flow Grignard and Lithiation: Screening Tools and Development of Continuous Processes for a Benzyl Alcohol Starting Material

3. Practical Synthesis of Chiral 2-Morpholine: (4-Benzylmorpholin-2-(S)-yl)-(tetrahydropyran-4-yl)methanone Mesylate, a Useful Pharmaceutical Intermediate

4. The continuous flow Barbier reaction: an improved environmental alternative to the Grignard reaction?

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