Continuous GMP Manufacturing for Grignard Reagent/Zincate Synthesis and Negishi Coupling Reaction-Reference-Cited by-同舟云学术

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Continuous GMP Manufacturing for Grignard Reagent/Zincate Synthesis and Negishi Coupling Reaction

Published:2024-01-22 Issue:5 Volume:28 Page:1734-1751
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Calvin Joel R.¹^ORCID,Boyse Raymond²,Braden Timothy M.¹^ORCID,Brewer Alison C.¹^ORCID,Changi Shujauddin¹,Harrold Donal²,Johnson Martin¹,Kerr Mark S.¹,Lambertus Gordon R.¹^ORCID,Luciani Carla V.¹^ORCID,May Scott A.¹^ORCID,Moloney Harold²,Murphy John D.²,Roberts Jeffrey C.¹,Schafer John P.¹³,Spencer Richard D.²,Webster Luke P.¹

Affiliation:

1. Synthetic Molecule Design and Development, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States

2. Technical Services/Manufacturing Sciences, Eli Lilly Kinsale Limited, Dunderrow, Kinsale, P17 NY71 Co. Cork, Ireland

3. D&M Continuous Solutions, LLC, Indianapolis, Indiana 46237, United States

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.3c00361

Reference31 articles.

1. End-to-End Continuous Manufacturing of Pharmaceuticals: Integrated Synthesis, Purification, and Final Dosage Formation

2. On-demand continuous-flow production of pharmaceuticals in a compact, reconfigurable system

3. An automated modular assembly line for drugs in a miniaturized plant

4. Continuous Production of Five Active Pharmaceutical Ingredients in Flexible Plug-and-Play Modules: A Demonstration Campaign

5. Kilogram-scale prexasertib monolactate monohydrate synthesis under continuous-flow CGMP conditions

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