Kilogram-scale prexasertib monolactate monohydrate synthesis under continuous-flow CGMP conditions-Reference-Cited by-同舟云学术

Kilogram-scale prexasertib monolactate monohydrate synthesis under continuous-flow CGMP conditions

Published:2017-06-16 Issue:6343 Volume:356 Page:1144-1150
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Cole Kevin P.¹^ORCID,Groh Jennifer McClary¹^ORCID,Johnson Martin D.¹^ORCID,Burcham Christopher L.¹^ORCID,Campbell Bradley M.¹^ORCID,Diseroad William D.²,Heller Michael R.¹,Howell John R.¹^ORCID,Kallman Neil J.¹^ORCID,Koenig Thomas M.³,May Scott A.¹,Miller Richard D.¹^ORCID,Mitchell David¹^ORCID,Myers David P.¹^ORCID,Myers Steven S.¹,Phillips Joseph L.¹,Polster Christopher S.¹^ORCID,White Timothy D.¹^ORCID,Cashman Jim⁴^ORCID,Hurley Declan⁵^ORCID,Moylan Robert⁵^ORCID,Sheehan Paul⁵^ORCID,Spencer Richard D.⁶^ORCID,Desmond Kenneth⁷,Desmond Paul⁷,Gowran Olivia⁷^ORCID

Affiliation:

1. Small Molecule Design and Development, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA.

2. Technical Services/Manufacturing Science, Eli Lilly and Company, Indianapolis, IN 46285, USA.

3. Technical Services/Manufacturing Science, Eli Lilly and Company, Greenfield, IN 46140, USA.

4. Quality Assurance, Eli Lilly and Company, Dunderrow, Kinsale, County Cork, Ireland.

5. Technical Services/Manufacturing Science, Eli Lilly and Company, Dunderrow, Kinsale, County Cork, Ireland.

6. Process Engineering, Eli Lilly and Company, Dunderrow, Kinsale, County Cork, Ireland.

7. Quality Control, Eli Lilly and Company, Dunderrow, Kinsale, County Cork, Ireland.

Abstract

Continuous-flow technology is devised and implemented for manufacture of a drug candidate in clinical trials.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference38 articles.

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5. Development of a Continuous Schotten–Baumann Route to an Acyl Sulfonamide

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