Reiterative Chiral Resolution/Racemization/Recycle (RRR Synthesis) for an Effective and Scalable Process for the Enantioselective Synthesis of a Dual IDO1/TDO2 Inhibitor Imidazoisoindole Derivative-Reference-Cited by-同舟云学术

Reiterative Chiral Resolution/Racemization/Recycle (RRR Synthesis) for an Effective and Scalable Process for the Enantioselective Synthesis of a Dual IDO1/TDO2 Inhibitor Imidazoisoindole Derivative

Published:2020-04-30 Issue:6 Volume:24 Page:1018-1023
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Crescenzi Cristina¹^ORCID,Fuchss Thomas²,Ippoliti Dimitri¹,Langella Annunziata¹,Di Mola Antonia³,Massa Antonio³^ORCID,Rozzi Diego¹

Affiliation:

1. Merck Serono S.p.A., Via Luigi Einaudi, 11, 00012 Guidonia Montecelio, RM, Italy, an affiliate of Merck KGaA, Darmstadt, Germany

2. Merck Healthcare KGaA, Frankfurter Str. 250, 64293 Darmstadt, Germany

3. Dipartimento di Chimica e Biologia “A. Zambelli”, Università degli studi di Salerno, Via Giovanni Paolo II, 84084 Fisciano, SA, Italy

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.0c00004

Reference22 articles.

1. Extensive Profiling of the Expression of the Indoleamine 2,3-Dioxygenase 1 Protein in Normal and Tumoral Human Tissues

2. Inhibitors of indoleamine-2,3-dioxygenase for cancer therapy: can we see the wood for the trees?

3. Indoleamine 2,3-dioxygenase and tumor-induced tolerance

4. Important Hydrogen Bond Networks in Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitor Design Revealed by Crystal Structures of Imidazoleisoindole Derivatives with IDO1

5. Richard, A.; Matilda, B.; Thomas, P.; Camille, G. 4H-Imidazo[1,5-a]indole Derivatives and Their use as Indoleamine 2,3-Dioxygenase (IDO) and/or Tryptophan 2,3-Dioxygenase (TDO2) Modulators. WO Patent WO20160511812016.

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3. Efficient preparation of ( R )‐2‐(2,5‐difluorophenyl)pyrrolidine via a recycle process of resolution;Chirality;2021-10-15