Continuous Flow Conditions for High Temperature Formation of a Benzodioxan Pharmaceutical Intermediate: Rapid Scaleup for Early Phase Material Delivery-Reference-Cited by-同舟云学术

Continuous Flow Conditions for High Temperature Formation of a Benzodioxan Pharmaceutical Intermediate: Rapid Scaleup for Early Phase Material Delivery

Published:2020-02-21 Issue:10 Volume:24 Page:1938-1947
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Li Pengbin¹,Yang Shaohui¹,Zhu Ruiheng¹,Sun Baoquan¹,Li Zhongbo¹,Huang Ping¹,Buser Jonas Y.²,Miguel Minguez Jose³,Ryan Sarah J.²^ORCID

Affiliation:

1. Shanghai SynTheAll Pharmaceutical Co., Ltd. (“STA”), No. 7 Building, #90 Delin Road, WaiGaoQiao Free Trade Zone, Shanghai, 200131, People’s Republic of China

2. Eli Lilly and Company, Small Molecule Design and Development (SMDD), Lilly Technology Center North, 1223 West Morris Street, Indianapolis, Indiana 46221, United States

3. Eli Lilly and Company, Discovery Chemistry Research and Technologies (DCRT), Avda. de la Industria 30, 28108 Alcobendas, Madrid, Spain

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.9b00499

Reference41 articles.

1. Estimation of clinical trial success rates and related parameters

2. Clinical development success rates for investigational drugs

3. Trends in clinical success rates

4. An innovative synthesis pathway to benzodioxanes: the peculiar reactivity of glycerol carbonate and catechol

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