Synthesis of Thiomorpholine via a Telescoped Photochemical Thiol–Ene/Cyclization Sequence in Continuous Flow

Author:

Steiner Alexander12,Nelson Ryan C.3,Dallinger Doris12ORCID,Kappe C. Oliver12ORCID

Affiliation:

1. Institute of Chemistry, University of Graz, NAWI Graz, Heinrichstrasse 28, 8010 Graz, Austria

2. Center for Continuous Flow Synthesis and Processing (CCFLOW), Research Center Pharmaceutical Engineering GmbH (RCPE), Inffeldgasse 13, 8010 Graz, Austria

3. Medicines for All Institute, Virginia Commonwealth University, 737 North Fifth Street, P.O. Box 980100, Richmond, Virginia 23298, United States

Funder

Bill and Melinda Gates Foundation

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Reference38 articles.

1. Oxazolidinone Antibiotics: Chemical, Biological and Analytical Aspects

2. Pearlman, B. A.; Perrault, W. R.; Barbachyn, M. R.; Manninen, P. R.; Toops, D. S.; Houser, D. J.; Fleck, T. J. Process to Prepare Oxazolidinones. U.S. Patent 5,837,870 A, 1998.

3. Arora, S. K.; Patil, V. J.; Nair, P. S.; Dixit, P. P.; Ajay, S.; Sinha, R. K. Antimycobacterial Compounds. U.S. Patent 7,691,889 B2, 2010.

4. Tetrahydro-1,4-thiazin (Thiamorpholin)

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