A Second Generation Synthesis of Benzyl Piperidine Derivatives: A Key Intermediate for the Preparation of SERT/5-HT1A Dual Inhibitor-Reference-Cited by-同舟云学术

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A Second Generation Synthesis of Benzyl Piperidine Derivatives: A Key Intermediate for the Preparation of SERT/5-HT1A Dual Inhibitor

Published:2015-08-12 Issue:8 Volume:19 Page:1030-1037
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Ueno Atsushi¹,Ae Nobuyuki¹,Terauchi Hideo¹,Fujimoto Koji¹,Fujiwara Yuji¹

Affiliation:

1. Process Chemistry Research and Development Laboratories, Sumitomo Dainippon Pharma Co., Ltd., 3-1-98 Kasugade-naka, Konohana-ku, Osaka 554-0022, Japan

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.5b00207

Reference21 articles.

1. Pindolol Induces a Rapid Improvement of Depressed Patients Treated With Serotonin Reuptake Inhibitors

2. Synthesis, Potency, and in Vivo Evaluation of 2-Piperazin-1-ylquinoline Analogues as Dual Serotonin Reuptake Inhibitors and Serotonin 5-HT1A Receptor Antagonists

3. aToyoda, T.; Yoshinaga, H.PCT Int. Appl. WO2009/099087, 2009.

4. bToyoda, T.; Nishida, T.; Yoshinaga, H.PCT Int. Appl. WO2011/016468, 2011.

5. First- and Second-Generation Practical Syntheses of Chroman-4-one Derivative: A Key Intermediate for the Preparation of SERT/5-HT1A Dual Inhibitors

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