A Continuous Flow Sulfuryl Chloride-Based Reaction—Synthesis of a Key Intermediate in a New Route toward Emtricitabine and Lamivudine
Author:
Affiliation:
1. Department of Chemical and Life Science Engineering, Virginia Commonwealth University, Richmond, Virginia 23284-3068, United States
2. Departamento de Quı́mica, Universidade Federal de São Carlos, 13565-905 São Carlos-SP, Brazil
Funder
Defense Advanced Research Projects Agency
Bill and Melinda Gates Foundation
Virginia Commonwealth University
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Physical and Theoretical Chemistry
Link
http://pubs.acs.org/doi/pdf/10.1021/acs.oprd.0c00146
Reference27 articles.
1. Emtricitabine
2. Lamivudine, an important drug in aids treatment
3. Emtricitabine (FTC) for the treatment of HIV infection
4. Twenty-Five Years of Lamivudine: Current and Future Use for the Treatment of HIV-1 Infection
5. Synthesis of an Oxathiolane Drug Substance Intermediate Guided by Constraint-Driven Innovation
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