Synthesis of an Oxathiolane Drug Substance Intermediate Guided by Constraint-Driven Innovation-Reference-Cited by-同舟云学术

Synthesis of an Oxathiolane Drug Substance Intermediate Guided by Constraint-Driven Innovation

Published:2020-05-13 Issue:10 Volume:24 Page:2266-2270
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Kashinath K.¹,Snead David R.¹^ORCID,Burns Justina M.¹,Stringham Rodger W.¹,Gupton B. Frank¹,McQuade D. Tyler¹^ORCID

Affiliation:

1. Medicines for All Institute, Virginia Commonwealth University, 737 North Fifth Street, Box 980100, Richmond, Virginia 23298, United States

Funder

Bill and Melinda Gates Foundation

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

http://pubs.acs.org/doi/pdf/10.1021/acs.oprd.0c00145

Reference37 articles.

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2. Expeditious preparation of (−)-2′-deoxy-3′-thiacytidine (3TC)

3. Enzyme-mediated enantioselective preparation of pure enantiomers of the antiviral agent 2',3'-dideoxy-5-fluoro-3'-thiacytidine (FTC) and related compounds

4. Asymmetric synthesis and biological evaluation of .beta.-L-(2R,5S)- and .alpha.-L-(2R,5R)-1,3-oxathiolane-pyrimidine and -purine nucleosides as potential anti-HIV agents

5. Enzymatic production of optically pure (2′R-cis)-2′-deoxy-3′-thiacytidine (3TC, lamivudine): A potent anti-HIV agent

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