Enantioselective Synthesis of <i>trans</i>-Disubstituted Cyclopropyltrifluoroborate Building Blocks through Ru-Catalyzed Cyclopropanation-Reference-Cited by-同舟云学术

Enantioselective Synthesis of trans-Disubstituted Cyclopropyltrifluoroborate Building Blocks through Ru-Catalyzed Cyclopropanation

Published:2022-10-04 Issue:10 Volume:26 Page:2979-2985
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Nguyen Thach¹^ORCID,Sreekumar Sanil¹,Wang Shuai¹,Jiang Qi²,Montel Florian³,Buono Frederic¹^ORCID

Affiliation:

1. Chemical Development, Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road, Ridgefield, Connecticut 06877-0378, United States

2. Material and Analytical Sciences, Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road, Ridgefield, Connecticut 06877-0378, United States

3. Discovery Research, Medicinal Chemistry, Boehringer Ingelheim Pharma GmbH & Co. KG, 65 Birkendorfer Strasse, Biberach an der Riss 88400, Germany

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.2c00265

Reference42 articles.

1. The “Cyclopropyl Fragment” is a Versatile Player that Frequently Appears in Preclinical/Clinical Drug Molecules

2. Modern Organic Synthesis with α-Diazocarbonyl Compounds

3. Highly Diastereo- and Enantioselective Synthesis of Trifluoromethyl-Substituted Cyclopropanes via Myoglobin-Catalyzed Transfer of Trifluoromethylcarbene

4. Highly Diastereo‐ and Enantioselective Synthesis of Nitrile‐Substituted Cyclopropanes by Myoglobin‐Mediated Carbene Transfer Catalysis

5. Stereoselective Cyclopropanation of Electron-Deficient Olefins with a Cofactor Redesigned Carbene Transferase Featuring Radical Reactivity

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