Development of a Scalable Process for the PPAR-α Agonist GW641597X Incorporating Baeyer–Villiger Chemistry and Retrospective ICH M7 Assessment-Reference-Cited by-同舟云学术

Development of a Scalable Process for the PPAR-α Agonist GW641597X Incorporating Baeyer–Villiger Chemistry and Retrospective ICH M7 Assessment

Published:2020-02-18 Issue:3 Volume:24 Page:371-386
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Boyer Thierry¹,Choudary Bernie M.²,Edwards Andrew J.³,Etridge Erika²,Etridge Steve²,Giddings Amanda⁴,Harvey Jim⁴,Hodnett Neil S.²³^ORCID,Druot-Houllemare Sophie²,Leahy John H.³,Payne Kathryn²,Reid Robert²³,Roberts Andrew D.³,Sasse Mike²,Simpson Alec³,Smith Steve²,Stevenson Neil G.³,Stonestreet Paul²,Urquhart Michael William²³^ORCID,White Angela⁴

Affiliation:

1. GlaxoSmithKline Research Centre, 25-27 Avenue du Quebec, 91951 Les Ulis, France

2. Chemical Development, GlaxoSmithKline Pharmaceuticals, Old Powder Mills, Nr. Leigh, Tonbridge, Kent TN11 9AN, United Kingdom

3. Research and Development, Medicines Research Centre, GlaxoSmithKline, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, United Kingdom

4. David Jack Centre for Research and Development, GlaxoSmithKline, Park Road, Ware, Hertfordshire SG12 0DP, United Kingdom

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.9b00385

Reference31 articles.

1. Substituted 2-[(4-Aminomethyl)phenoxy]-2-methylpropionic Acid PPARα Agonists. 1. Discovery of a Novel Series of Potent HDLc Raising Agents

2. Functional group oxidation using sodium perborate1

3. Peracetic acid is explosive above 110 °C (Lewis, R. J., Ed. Hawley’s Condensed Chemical Dictionary, 12th ed.; Van Nostrand Reinhold: New York, 1993; pp 883–884). Its safety data sheet (PeroxyChem) highlights potentially hazardous conditions to avoid, which may lead to explosive reactions. These include contact with metals, metallic ions, alkalis, reducing agents, and organic matter (such as alcohols or terpenes), which may produce self-accelerated thermal decomposition.

4. Use of 4-Cyanocoumarins as Dienophiles in a Facile Synthesis of Highly Substituted Dibenzopyranones

Cited by 5 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Leveraging ICH M7 Control Options 3 and 4: Discussion and Clarification Using Industrial Case Studies;Organic Process Research & Development;2024-07-23

2. Development of a First-Generation Stereocontrolled Manufacturing Process of TRPA1 Inhibitor GDC-6599;Organic Process Research & Development;2024-05-24

3. Establishing Best Practice for the Application and Support of Solubility Purge Factors;Organic Process Research & Development;2023-03-14

4. Use of Lhasa Limited Products for the In Silico Prediction of Drug Toxicity;Methods in Molecular Biology;2022

5. Mutagenic Impurities – Assessment of Fate and Control Options;Mutagenic Impurities;2021-12-08