Substituted 2-[(4-Aminomethyl)phenoxy]-2-methylpropionic Acid PPARα Agonists. 1. Discovery of a Novel Series of Potent HDLc Raising Agents-Reference-Cited by-同舟云学术

Substituted 2-[(4-Aminomethyl)phenoxy]-2-methylpropionic Acid PPARα Agonists. 1. Discovery of a Novel Series of Potent HDLc Raising Agents

Published:2007-01-23 Issue:4 Volume:50 Page:685-695
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Sierra Michael L.¹,Beneton Véronique¹,Boullay Anne-Bénédict¹,Boyer Thierry¹,Brewster Andrew G.¹,Donche Frédéric¹,Forest Marie-Claire¹,Fouchet Marie-Hélène¹,Gellibert Françoise J.¹,Grillot Didier A.¹,Lambert Millard H.¹,Laroze Alain¹,Le Grumelec Christelle¹,Linget Jean Michel¹,Montana Valerie G.¹,Nguyen Van-Loc¹,Nicodème Edwige¹,Patel Vipul¹,Penfornis Annie¹,Pineau Olivier¹,Pohin Danig¹,Potvain Florent¹,Poulain Géraldine¹,Ruault Cécile Bertho¹,Saunders Michael¹,Toum Jérôme¹,Xu H. Eric¹,Xu Robert X.¹,Pianetti Pascal M.¹

Affiliation:

1. Department of Medicinal Chemistry, Department of Biology, Department of Drug Metabolism and Pharmacokinetics, Laboratoire GlaxoSmithKline, Centre de Recherches, 25-27 avenue du Québec, 91951 Les Ulis, France, Department of Medicinal Chemistry, GlaxoSmithKline Research and Development, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2N7, United Kingdom, and Department of Computational, Analytical and Structural Sciences, GlaxoSmithKline, 5 Moore Drive, Research Triangle Park,...

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm058056x

Reference26 articles.

1. Lovastatin and beyond: the history of the HMG-CoA reductase inhibitors

2. Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators

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