Optimization of an Aminothiazine Ring Formation: Integrating Modeling with Experiments to Maximize Yield by Minimizing Impurity Formation
Author:
Affiliation:
1. Eli Lilly and Company, Small Molecule Design and Development, Indianapolis, Indiana 46285, United States
2. RES Group, Inc. 75 Second Avenue, Needham, Massachusetts 02494, United States
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Physical and Theoretical Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.5b00036
Reference14 articles.
1. Mergott, D. J. and Vaught, G. M.BACE Inhibitors. US 2012/8278441.
2. Synthesis of BACE Inhibitor LY2886721. Part I. An Asymmetric Nitrone Cycloaddition Strategy
3. Synthesis of BACE Inhibitor LY2886721. Part II. Isoxazolidines as Precursors to Chiral Aminothiazines, Selective Peptide Coupling, and a Controlled Reactive Crystallization
4. A Convenient Method for the Preparation of Primary and Symmetrical N,N′-Disubstituted Thioureas
5. Synthesis of novel imidazo[1,2-a][3,1]benzothiazines 4, imidazo[1,2-a]-[1,2,4]benzotriazines 5, and 4H-imidazo[2,3-c]pyrido[2,3-e][1,4]oxazines 6
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