Process Development for Synthesizing the Cephalosporin Antibiotic Cefotaxime in Batch and Flow Mode-Reference-Cited by-同舟云学术

Process Development for Synthesizing the Cephalosporin Antibiotic Cefotaxime in Batch and Flow Mode

Published:2018-07-23 Issue:8 Volume:22 Page:947-954
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Pieper Matthias¹,Kumpert Mario²,König Burghard³,Schleich Herbert³,Bayer Thomas²,Gröger Harald¹^ORCID

Affiliation:

1. Chair of Organic Chemistry I, Faculty of Chemistry, Bielefeld University, Universitätsstr. 25, 33615 Bielefeld, Germany

2. Fachbereich Chemieingenieurwesen, Provadis School of International Management and Technology AG, Industriepark Höchst, Gebäude B 835, 65926 Frankfurt am Main, Germany

3. Anti-Infectives Business Unit, Sandoz GmbH, Biochemiestrasse10, 6250 Kundl, Austria

Funder

Deutsche Bundesstiftung Umwelt

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.8b00064

Reference25 articles.

1. Antibacterial Natural Products in Medicinal Chemistry—Exodus or Revival?

2. Industrial landmarks in the development of sustainable production processes for the β-lactam antibiotic key intermediate 7-aminocephalosporanic acid (7-ACA)

3. aMiao, D.; Wang, L.; Xu, J.; Zeng, X. Preparation technology of cefotaxime. PCT Int. Appl. CN101560217, 2009.

4. bZhang, J.; Liu, Q.; Wang, Y.; Gao, J. Method for preparing cefotaxime acid. PCT Int. Appl. CN102702230, 2012.

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