Improved Multigram Route to a Tricyclic Key Intermediate for Dibenzosuberone-Based p38 Inhibitors via an Optimized Early-Stage Heck Coupling-Reference-Cited by-同舟云学术

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Improved Multigram Route to a Tricyclic Key Intermediate for Dibenzosuberone-Based p38 Inhibitors via an Optimized Early-Stage Heck Coupling

Published:2021-08-04 Issue:8 Volume:25 Page:1831-1840
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Forster Michael¹,Wentsch-Teltschik Heike K.¹,Laufer Stefan A.¹²³^ORCID

Affiliation:

1. Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmaceutical Sciences, Eberhard Karls Universität, 72076 Tübingen, Germany

2. Cluster of Excellence iFIT (EXC 2180) “Image-Guided and Functionally Instructed Tumor Therapies”, University of Tübingen, 72076 Tübingen, Germany

3. Tübingen Center for Academic Drug Discovery & Development (TüCAD2), 72076 Tübingen, Germany

Funder

Bundesministerium fÃ¼r Bildung und Forschung

Deutsche Forschungsgemeinschaft

Baden-WÃ¼rttemberg Stiftung

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.1c00081

Reference18 articles.

1. p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases

2. Inhibition of p38: Has the fat lady sung?

3. The as-yet unfulfilled promise of p38 MAPK inhibitors

4. Diversity and versatility of p38 kinase signalling in health and disease

5. The p38 Pathway: From Biology to Cancer Therapy

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Efficient, Economic, and Large-scale Synthesis of 2, 4-Dichloro-10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-one;Organic Preparations and Procedures International;2023-05-22

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