Toward a Practical, Two-Step Process for Molnupiravir: Direct Hydroxamination of Cytidine Followed by Selective Esterification-Reference-Cited by-同舟云学术

Toward a Practical, Two-Step Process for Molnupiravir: Direct Hydroxamination of Cytidine Followed by Selective Esterification

Published:2021-07-28 Issue:8 Volume:25 Page:1822-1830
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Paymode Dinesh J.¹^ORCID,Vasudevan N.¹,Ahmad Saeed¹,Kadam Appasaheb L.¹^ORCID,Cardoso Flavio S.P.¹^ORCID,Burns Justina M.¹,Cook Daniel W.¹^ORCID,Stringham Rodger W.¹,Snead David R.¹^ORCID

Affiliation:

1. Medicines For All Institute, 737 N 5th Street, Box 980100, Richmond, Virginia 23298, United States

Funder

Bill and Melinda Gates Foundation

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.1c00033

Reference45 articles.

1. An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice

2. Therapeutically administered ribonucleoside analogue MK-4482/EIDD-2801 blocks SARS-CoV-2 transmission in ferrets

3. Mutagenic action of N4-hydroxycytidine on Escherichia coli B cyt−

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