Development of the Convergent, Kilogram-Scale Synthesis of an Antibacterial Clinical Candidate Using Enantioselective Hydrogenation-Reference-Cited by-同舟云学术

Development of the Convergent, Kilogram-Scale Synthesis of an Antibacterial Clinical Candidate Using Enantioselective Hydrogenation

Published:2020-03-04 Issue:4 Volume:24 Page:588-598
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Benson Helen¹,Bones Karen²,Churchill Gwydion²,Ford Gair²,Frodsham Lianne²,Janbon Sophie¹^ORCID,Millington Fiona²,Powell Lyn²,Raw Steven A.²^ORCID,Reid Julie²,Stark Andrew¹,Steven Alan²^ORCID

Affiliation:

1. Early Chemical Development, Pharmaceutical Sciences, R&D, AstraZeneca, Macclesfield SK10 2NA, U.K.

2. Pharmaceutical Technology & Development, AstraZeneca Macclesfield Campus, Charter Way, Macclesfield SK10 2NA, U.K.

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.0c00029

Reference38 articles.

1. The Antibiotic Future

2. Chapter 19 Recent Advances in the Inhibition of Bacterial Type II Topoisomerases

3. Comita-Prevoir, J.; Cronin, M.; Geng, B.; Godfrey, A. A.; Reck, F. Preparation of 2-quinolinone and 2-quinoxalinone derivatives as antibacterial agents. WO 2008071961 A1.

4. Dartois, C. G. Y.; Markwell, R. E.; Madler, G. M. M. G.; Pearson, N. D. Preparation of bicyclic nitrogen-containing heterocyclic derivatives for use as antibacterials. WO 2002096907 A1.

5. Novel N-Linked Aminopiperidine Inhibitors of Bacterial Topoisomerase Type II with Reduced pKa: Antibacterial Agents with an Improved Safety Profile

Cited by 17 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Discovery of aminopiperidine based potent & novel topoisomerase inhibitor with broad spectrum anti-bacterial activity;Bioorganic & Medicinal Chemistry Letters;2024-10

2. Reversal of the Regioselectivity of Iron‐Promoted Hydrogenation and Hydrohalogenation of gem‐Difluoroalkenes;Angewandte Chemie International Edition;2024-05-16

3. Reversal of the Regioselectivity of Iron‐Promoted Hydrogenation and Hydrohalogenation of gem‐Difluoroalkenes;Angewandte Chemie;2024-05-16

4. Research Progress of Continuous Flow Selective Hydrogenation Technology;Chinese Journal of Organic Chemistry;2024

5. Enantioselective Transformations in the Synthesis of Therapeutic Agents;Chemical Reviews;2023-07-07