Novel N-Linked Aminopiperidine Inhibitors of Bacterial Topoisomerase Type II with Reduced pKa: Antibacterial Agents with an Improved Safety Profile-Reference-Cited by-同舟云学术

Novel N-Linked Aminopiperidine Inhibitors of Bacterial Topoisomerase Type II with Reduced pKa: Antibacterial Agents with an Improved Safety Profile

Published:2012-07-20 Issue:15 Volume:55 Page:6916-6933
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Reck Folkert,Alm Richard A.,Brassil Patrick,Newman Joseph V.,Ciaccio Paul,McNulty John,Barthlow Herbert,Goteti Kosalaram,Breen John,Comita-Prevoir Janelle,Cronin Mark,Ehmann David E.,Geng Bolin,Godfrey Andrew Aydon¹,Fisher Stewart L.

Affiliation:

1. Pharmaceutical Development, Chemical Sciences, AstraZeneca, Silk Road Business Park, Macclesfield, SK10 4TG Cheshire, England

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm300690s

Reference29 articles.

1. Prevalence of Antimicrobial-Resistant Pathogens in Canadian Hospitals: Results of the Canadian Ward Surveillance Study (CANWARD 2008)

2. MRSA: the first half century

3. Resistance to Linezolid Is Mediated by thecfrGene in the First Report of an Outbreak of Linezolid‐ResistantStaphylococcus aureus

4. Inhibition of Daptomycin by Pulmonary Surfactant: In Vitro Modeling and Clinical Impact

5. Novel N-Linked Aminopiperidine Inhibitors of Bacterial Topoisomerase Type II: Broad-Spectrum Antibacterial Agents with Reduced hERG Activity

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