Improved Synthesis of 6-Chloro-5-methylpyridin-2-amine: A Key Intermediate for Making Lumacaftor-Reference-Cited by-同舟云学术

Improved Synthesis of 6-Chloro-5-methylpyridin-2-amine: A Key Intermediate for Making Lumacaftor

Published:2020-04-24 Issue:6 Volume:24 Page:1175-1179
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Zhang Junchi¹²,Zhu Fuqiang³^ORCID,Tian Guanghui³,Jiang Xiangrui¹²^ORCID,Shen Jingshan¹²^ORCID

Affiliation:

1. CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CAS), 555 Zuchongzhi Road, Shanghai 201203, People’s Republic of China

2. University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, People’s Republic of China

3. Topharman Shanghai Co., Ltd., Building 1, No. 388 Jialilue Road, Zhangjiang Hitech Park, Shanghai 201203, People’s Republic of China

Funder

Chinese Academy of Sciences

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.9b00556

Reference21 articles.

1. Lumacaftor/Ivacaftor: A Review in Cystic Fibrosis

2. Orkambi (lumacaftor/ivacaftor) Oral Tablet: Drug approval by FDA. https://www.accessdata.fda.gov/drugsatfda_docs/nda/2015/0206038Orig1s000TOC.cfm (accessed 2020-04-24).

3. Cystic fibrosis

4. Orkambi (lumacaftor/ivacaftor) Oral Tablet: Drug approval by EMA. https://www.ema.europa.eu/en/documents/smop-initial/chmp-summary-positive-opinion-orkambi_en.pdf (accessed 2020-04-24).

5. CFTR modulator therapy in patients with cystic fibrosis and an organ transplant

Cited by 6 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Process Development of a Tricyclic Diazepine-Based IDH1 Mutant Inhibitor;Organic Process Research & Development;2024-06-06

2. Experimental and Theoretical Analysis on Mild Steel Corrosion Inhibition by Two Novel Compounds (FD and ACP) in Acidic Media;Portugaliae Electrochimica Acta;2023

3. Palladium-Catalyzed Carbonylation of Aryl Bromides with Carbon Dioxide To Access Aryl Carboxylic Acids under Mild Conditions;The Journal of Organic Chemistry;2022-10-26

4. Recent Applications of Pd-Catalyzed Suzuki–Miyaura and Buchwald–Hartwig Couplings in Pharmaceutical Process Chemistry;Organics;2022-01-18

5. Directing Group Enables Electrochemical Selectively Meta-Bromination of Pyridines under Mild Conditions;The Journal of Organic Chemistry;2021-06-15