Optimization of the Preparation of (R)-3,5-Bis(trifluoromethyl)-α-methyl-N-methylbenzylamine l-(−)-Malic Acid Salt through Classical Resolution-Reference-Cited by-同舟云学术

Optimization of the Preparation of (R)-3,5-Bis(trifluoromethyl)-α-methyl-N-methylbenzylamine l-(−)-Malic Acid Salt through Classical Resolution

Published:2015-11-03 Issue:12 Volume:19 Page:1954-1965
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Brandel Clément M.¹,Cooke Jason W. B.¹,Horan Richard A. J.¹,Mallet Franck P.¹,Stevens David R.¹

Affiliation:

1. Global API Chemistry, GlaxoSmithKline Research and Development, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, United Kingdom

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.5b00283

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2. Synthesis of the NK1 Receptor Antagonist GW597599. Part 3: Development of a Scalable Route to a Key Chirally Pure Arylpiperazine Urea, A Happy End

3. Discovery and Biological Characterization of (2R,4S)-1′-Acetyl-N-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-2-(4-fluoro-2-methylphenyl)-N-methyl-4,4′-bipiperidine-1-carboxamide as a New Potent and Selective Neurokinin 1 (NK1) Receptor Antagonist Clinical Candidate

4. Application of the QbD Principles in the Development of the Casopitant Mesylate Manufacturing Process. Process Research Studies for the Definition of the Control Strategy of some Drug Substance-CQAs for Stages 2a, 2b, and 2c

5. Christensen, S. R.; Merlo Pich, E.; Ratti, E.; Yamada, T.Preparation of Carbamoylpiperazine Derivatives as NK1 Receptor Antagonists, International Patent Application WO 2008/046882, April 24, 2008;Chem. Abstr. 2008, 148, 495980.

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