An Improved Convergent Synthesis of AZD7762: A One-Pot Construction of a Highly Substituted Thiophene at the Multikilogram Scale
Author:
Affiliation:
1. Pharmaceutical Technology and Development, AstraZeneca, Silk Road Business Park, Macclesfield, Cheshire, SK10 2NA, United Kingdom
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Physical and Theoretical Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.6b00364
Reference10 articles.
1. Ashwell, S.; Gero, T.; Ioannidis, S.; Janetka, J.; Lyne, P.; Su, M.; Toader, D.; Yu, D.; Yu, Y.P. Int. Appl. WO2005066163, 2005.
2. A Simple Method for the Synthesis of 5-Aryl-3-amino-2-alkoxycarbonylthiophenes
3. Discovery and SAR of a Novel Selective and Orally Bioavailable Nonpeptide Classical Competitive Inhibitor Class of Protein-Tyrosine Phosphatase 1B
4. New Approach to 3‐Aminothiophene‐ 2‐carboxylic Acid Derivatives: Access to 5‐Aryl‐4‐(ethylsulfanyl) Compounds
5. Synthetische reaktionen von dimethylformamid IV. Darstellung von β-chlorvinylaldehyden aus carbonylverbindungen
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