Discovery and SAR of a Novel Selective and Orally Bioavailable Nonpeptide Classical Competitive Inhibitor Class of Protein-Tyrosine Phosphatase 1B

Author:

Andersen Henrik Sune1,Olsen Ole H.1,Iversen Lars F.1,Sørensen Anette L. P.1,Mortensen Steen B.1,Christensen Michael S.1,Branner Sven1,Hansen Thomas K.1,Lau Jesper F.1,Jeppesen Lone1,Moran Edmond J.1,Su Jing1,Bakir Farid1,Judge Luke1,Shahbaz Manou1,Collins Tassie1,Vo Todd1,Newman Michael J.1,Ripka William C.1,Møller Niels Peter H.1

Affiliation:

1. Departments of Medicinal Chemistry Research 1, 4, and 5 and Drug Metabolism, Health Care Discovery, Novo Nordisk A/S, Novo Nordisk Park, DK-2760 Måløv, Denmark, Departments of Protein Structure, Protein Design, and Signal Transduction, Novo Nordisk A/S, Novo Allé, DK-2880 Bagsværd, Denmark, and Ontogen Corporation, 2325 Camino Vida Roble, Carlsbad, California 92009

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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