3-Benzylaminomethyl Lithocholic Acid Derivatives Exhibited Potent and Selective Uncompetitive Inhibitory Activity Against Protein Tyrosine Phosphatase 1B (PTP1B)-Reference-Cited by-同舟云学术

3-Benzylaminomethyl Lithocholic Acid Derivatives Exhibited Potent and Selective Uncompetitive Inhibitory Activity Against Protein Tyrosine Phosphatase 1B (PTP1B)

Published:2024-07-21 Issue: Volume: Page:
ISSN:2470-1343
Container-title:ACS Omega
language:en
Short-container-title:ACS Omega

Author:

Mendoza-Jasso María-Eugenia¹²³,Pérez-Villanueva Jaime²,Alvarado-Rodríguez José G.⁴^ORCID,González-Andrade Martin³,Cortés-Benítez Francisco²^ORCID

Affiliation:

1. Doctorado en Ciencias Farmacéuticas, División de Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana − Unidad Xochimilco, Ciudad de México 04960, Mexico

2. Laboratorio de Síntesis y Aislamiento de Sustancias Bioactivas, Departamento de Sistemas Biológicos, División de Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana − Unidad Xochimilco, Ciudad de México 04960, Mexico

3. Laboratorio de Biosensores y Modelaje Molecular, Departamento de Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México 04510, Mexico

4. Área académica de Química, Universidad Autónoma del Estado de Hidalgo, Hidalgo 42184, Mexico

Funder

Universidad Aut??noma Metropolitana

Universidad Nacional Aut??noma de M??xico

Consejo Nacional de Humanidades Ciencias y Tecnolog??as

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acsomega.4c04948

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5. Synthesis and biological evaluation of novel 2,3-pyrazole ring-substituted-4,4-dimethyl lithocholic acid derivatives as selective protein tyrosine phosphatase 1B (PTP1B) inhibitors with cellular efficacy